Antioxidants and AP-1 activation: a brief overview

Immunobiology. 1997 Dec;198(1-3):273-8. doi: 10.1016/S0171-2985(97)80047-2.


Activity of the transcription factor AP-1 is controlled by different MAPK cascades that regulate the different AP-1 components at the transcriptional and posttranscriptional level. Recently, AP-1 has been shown to behave as a redox-sensitive transcription factor that can be induced under both pro-oxidative and antioxidative conditions. In this overview we summarize the signaling pathways that converge on the activation of AP-1 and the components of these pathways that have been shown to be targets of antioxidants. The activation of AP-1 by antioxidants may account for the expression of a number of genes that mediate important functions under physiological conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants / metabolism*
  • Gene Expression
  • Humans
  • Signal Transduction
  • Transcription Factor AP-1 / metabolism*


  • Antioxidants
  • Transcription Factor AP-1