Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 13, 83-117

Microtubule Polymerization Dynamics


Microtubule Polymerization Dynamics

A Desai et al. Annu Rev Cell Dev Biol.


The polymerization dynamics of microtubules are central to their biological functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that can change rapidly in response to cellular needs and, in some cases, to perform mechanical work. Microtubules utilize the energy of GTP hydrolysis to fuel a unique polymerization mechanism termed dynamic instability. In this review, we first describe progress toward understanding the mechanism of dynamic instability of pure tubulin and then discuss the function and regulation of microtubule dynamic instability in living cells.

Similar articles

See all similar articles

Cited by 685 articles

See all "Cited by" articles

Publication types

LinkOut - more resources