Cyclin-dependent kinases: engines, clocks, and microprocessors

Annu Rev Cell Dev Biol. 1997:13:261-91. doi: 10.1146/annurev.cellbio.13.1.261.


Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cyclin-Dependent Kinases / chemistry
  • Cyclin-Dependent Kinases / physiology*
  • Cyclins / chemistry
  • Cyclins / metabolism
  • Enzyme Activation
  • Humans
  • Molecular Structure


  • Cyclins
  • Cyclin-Dependent Kinases