Initiation of DNA replication in eukaryotic cells

Annu Rev Cell Dev Biol. 1997;13:293-332. doi: 10.1146/annurev.cellbio.13.1.293.

Abstract

The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology
  • Cell Cycle Proteins / physiology
  • DNA Replication*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Homeostasis
  • Humans
  • Origin Recognition Complex
  • Saccharomyces cerevisiae Proteins*

Substances

  • CDC6 protein, S cerevisiae
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Origin Recognition Complex
  • Saccharomyces cerevisiae Proteins