Rhabdomyolysis in autosomal dominant progressive external ophthalmoplegia

Neurology. 1998 Jan;50(1):299-300. doi: 10.1212/wnl.50.1.299.


Multiple mtDNA deletions have been reported to be a cause of inherited recurrent myoglobinuria. We report a 57-year-old man with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions who developed acute rhabdomyolysis provoked by alcohol. A repeated alcohol intake resulted in a 57-fold increase in serum myoglobin. Patients with mitochondrial myopathy and multiple mtDNA deletions, regardless of associated phenotype and mode of inheritance, may develop rhabdomyolysis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / therapy
  • Central Nervous System Depressants / adverse effects*
  • Chromosome Aberrations
  • Chromosome Disorders
  • DNA, Mitochondrial / genetics
  • Ethanol / adverse effects*
  • Gene Deletion
  • Genes, Dominant
  • Humans
  • Male
  • Middle Aged
  • Myoglobinuria / blood
  • Myoglobinuria / etiology
  • Ophthalmoplegia / complications
  • Ophthalmoplegia / genetics*
  • Renal Dialysis
  • Rhabdomyolysis / chemically induced*
  • Rhabdomyolysis / genetics*


  • Central Nervous System Depressants
  • DNA, Mitochondrial
  • Ethanol