A clinical trial of hypertonic saline nasal spray in subjects with the common cold or rhinosinusitis

Arch Fam Med. Jan-Feb 1998;7(1):39-43. doi: 10.1001/archfami.7.1.39.


Objective: To determine whether hypertonic saline nasal spray relieves nasal symptoms and shortens illness duration in patients with the common cold or acute rhinosinusitis.

Design: Randomized trial with 2 control groups.

Setting: Two family practice clinics.

Participants: One hundred forty-three adult patients with a cold or sinus infection. Patients with allergic rhinitis, symptoms for more than 3 weeks, or other respiratory diagnoses were excluded, as were those who had used topical decongestants.

Intervention: Hypertonic saline or normal saline spray 3 times a day or observation. Subjects completed a 7-day symptom checklist that included a well-being question ("Do you feel back to normal?").

Main outcome measures: Nasal symptom score (sum of scores for nasal congestion, rhinorrhea, and headache) on day 3 and day of well-being (day of symptom resolution).

Results: Data were collected for 119 subjects. No difference was found in either primary outcome when hypertonic saline was compared with either normal saline or observation. Mean day of well-being was 8.3 (95% confidence interval [CI], 6.9-9.7), 9.2 (95% CI, 6.9-11.43), and 8.0 (95% CI, 6.7-9.3) days in the hypertonic saline, normal saline, and observation groups, respectively. Day 3 mean nasal symptom score was 3.8 (95% CI, 3.0-4.5) for hypertonic saline, 3.7 (95% CI, 2.9-4.5) for normal saline, and 4.1 (95% CI, 3.5-4.7) for observation. Only 44% of the patients would use the hypertonic saline spray again. Thirty-two percent noted burning, compared with 13% of the normal saline group (P = .05).

Conclusion: Hypertonic saline does not improve nasal symptoms or illness duration in patients with the common cold or rhinosinusitis.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intranasal
  • Adult
  • Common Cold / therapy*
  • Female
  • Humans
  • Male
  • Rhinitis / therapy*
  • Saline Solution, Hypertonic / administration & dosage*
  • Saline Solution, Hypertonic / adverse effects
  • Sinusitis / therapy*
  • Time Factors
  • Treatment Failure


  • Saline Solution, Hypertonic