Selective serotonin reuptake inhibitors: infrequent medical adverse effects

Arch Fam Med. Jan-Feb 1998;7(1):78-84. doi: 10.1001/archfami.7.1.78.


The selective serotonin reuptake inhibitors have a very favorable safety profile. However, because of the wide use of this drug group, even low-frequency adverse effects become more prevalent. This article reviews 5 of these relatively infrequent adverse medical effects associated with the use of selective serotonin reuptake inhibitors: the syndrome of inappropriate antidiuretic hormone secretion, extrapyramidal effects, bleeding complications, cardiac arrhythmias, and the serotonin syndrome.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac / chemically induced
  • Diagnosis, Differential
  • Hemorrhage / chemically induced
  • Humans
  • Inappropriate ADH Syndrome / chemically induced
  • Serotonin / physiology
  • Serotonin Uptake Inhibitors / adverse effects*
  • Spinal Cord Diseases / chemically induced
  • Syndrome


  • Serotonin Uptake Inhibitors
  • Serotonin