Ribonucleoprotein Assembly: Clues From Spinal Muscular Atrophy

Curr Biol. 1998 Jan 29;8(3):R93-5. doi: 10.1016/s0960-9822(98)70055-7.

Abstract

Mutation or deletion of one of the two genes encoding a protein known as SMN has recently been shown to cause spinal muscular atrophy. The SMN protein has been found to be part of a multi-component complex that appears to function in the assembly of cellular ribonucleoprotein particles.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclic AMP Response Element-Binding Protein
  • Humans
  • Macromolecular Substances
  • Multigene Family
  • Muscular Atrophy, Spinal / genetics
  • Muscular Atrophy, Spinal / metabolism*
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • Oocytes
  • Polymorphism, Genetic
  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear / metabolism*
  • SMN Complex Proteins
  • Xenopus laevis

Substances

  • Cyclic AMP Response Element-Binding Protein
  • GEMIN2 protein, human
  • Macromolecular Substances
  • Nerve Tissue Proteins
  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear
  • SMN Complex Proteins