Abstract
Cyclooxygenase catalyses a key step in prostaglandin biosynthesis, and recent work suggests that one isoenzyme, COX-2, has important roles in early stages of pregnancy; it also appears to be involved in the somewhat analogous process of colon tumor formation and spread.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Cell Transformation, Neoplastic / metabolism
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Colonic Neoplasms / etiology
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Colonic Neoplasms / metabolism*
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Colonic Neoplasms / prevention & control
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Cyclooxygenase 1
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Cyclooxygenase 2
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors / pharmacology
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Cyclooxygenase Inhibitors / therapeutic use
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Embryo Implantation
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Female
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Genes, APC
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Humans
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Infertility, Female / enzymology
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Infertility, Female / genetics
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Isoenzymes / physiology
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Membrane Proteins
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Mice
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Mice, Knockout
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Neoplasm Proteins / physiology
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Pregnancy / metabolism*
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Pregnancy, Animal
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Prostaglandin-Endoperoxide Synthases / physiology
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Prostaglandins / physiology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase 2 Inhibitors
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Cyclooxygenase Inhibitors
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Isoenzymes
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Membrane Proteins
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Neoplasm Proteins
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Prostaglandins
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Cyclooxygenase 1
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Cyclooxygenase 2
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PTGS1 protein, human
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PTGS2 protein, human
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Prostaglandin-Endoperoxide Synthases
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Ptgs1 protein, mouse