Riedel's lobe should be considered in all patients undergoing cross-sectional imaging. It may harbor a lesion that might not be demonstrated unless the most inferior aspect of the liver is imaged. We have tried to identify the prevalence of Riedel's lobe in a series of patients with normal abdominopelvic computed tomographic (CT) findings. We reviewed the digital CT data of 105 patients, ages 20-89 years, to define the position of the liver in relation to the costal margin and the iliac crest. There were no significant differences in the prevalence of Riedel's lobe between sexes. The proportion of individuals in whom the most caudal margin of the liver was inferior to the most caudal costal margin was age-dependent and increased to 65% in the 50-59 age group. The craniocaudal dimension of the liver decreased with age (P < 0.02). Riedel's lobe appears to be a common variant of normal anatomy, its prevalence being dependent on age-related changes in liver size and skeletal shape.