Circulating cytokines in Alzheimer's disease

J Psychiatr Res. Nov-Dec 1997;31(6):657-60. doi: 10.1016/s0022-3956(97)00023-x.

Abstract

Immune factors may be involved in the pathophysiology of Alzheimer's disease (AD), a neurodegenerative disease. Since immune activation precedes immune-mediated processes, we measured plasma levels of four selective cytokines: interleukin-6 (IL-6), interleukin-12 (IL-12), interferon-alpha (IFN-alpha), and interferon-gamma (IFN-gamma). The level of IL-6, but not other cytokines, was significantly elevated. The increase of circulating IL-6 indicates immune activation presumably related to pathophysiology of the disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / blood
  • Alzheimer Disease / immunology*
  • Blood-Brain Barrier
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interferon-alpha / blood
  • Interferon-alpha / immunology*
  • Interferon-alpha / metabolism
  • Interferon-gamma / blood
  • Interferon-gamma / immunology*
  • Interferon-gamma / metabolism
  • Interleukins / blood
  • Interleukins / immunology*
  • Interleukins / metabolism
  • Male
  • Middle Aged
  • T-Lymphocytes / immunology
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Interferon-alpha
  • Interleukins
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma