Genetic characterization of late-flowering traits induced by DNA hypomethylation mutation in Arabidopsis thaliana

Plant J. 1997 Dec;12(6):1447-51. doi: 10.1046/j.1365-313x.1997.12061447.x.


Arabidopsis DNA hypomethylation mutation, ddm1, results in a variety of developmental abnormalities by slowly inducing heritable lesions at unlinked loci. Here, late-flowering traits observed at high frequencies in independently-established ddm1 lines were genetically characterized. In all of the four late-flowering lines examined the traits were dominant and mapped to the same chromosomal region, which is close or possibly identical to the FWA locus. The ddm1-induced phenotypic onsets are apparently not random mutation events, but specific to a group of genes, suggesting the underlying epigenetic mechanism. The DNA methylation mutant provide useful system for identifying epigenetically-regulated genes important for plant development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / genetics
  • Arabidopsis / physiology*
  • Crosses, Genetic
  • DNA Methylation*
  • DNA, Plant / chemistry
  • DNA, Plant / genetics
  • Mutation*
  • Phenotype
  • Plant Stems


  • DNA, Plant