Dickkopf-1 Is a Member of a New Family of Secreted Proteins and Functions in Head Induction

Nature. 1998 Jan 22;391(6665):357-62. doi: 10.1038/34848.

Abstract

The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cloning, Molecular
  • Embryonic Development
  • Embryonic Induction*
  • Head / embryology
  • Intercellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Multigene Family
  • Proteins / genetics
  • Proteins / metabolism
  • Proteins / physiology*
  • Proto-Oncogene Proteins / antagonists & inhibitors*
  • Proto-Oncogene Proteins / metabolism
  • Signal Transduction
  • Wnt Proteins
  • Xenopus
  • Xenopus Proteins
  • Zebrafish Proteins*

Substances

  • Intercellular Signaling Peptides and Proteins
  • Proteins
  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Xenopus Proteins
  • Zebrafish Proteins
  • dkk1 protein, Xenopus
  • dkk1b protein, zebrafish

Associated data

  • GENBANK/AF030433
  • GENBANK/AF030434