Hyperammonemic encephalopathy after chemotherapy. Survival after treatment with sodium benzoate and sodium phenylacetate

J Clin Gastroenterol. 1997 Dec;25(4):682-4. doi: 10.1097/00004836-199712000-00026.

Abstract

A 16-year-old boy had hyperammonemia and encephalopathy develop after high-dose chemotherapy for acute lymphoblastic leukemia. He was treated successfully with the ammonia-trapping agents sodium benzoate and sodium phenylacetate.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Ammonia / blood*
  • Antimetabolites / therapeutic use*
  • Benzoates / therapeutic use*
  • Benzoic Acid
  • Brain Diseases / chemically induced
  • Brain Diseases / drug therapy*
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Male
  • Phenylacetates / therapeutic use*

Substances

  • Antimetabolites
  • Benzoates
  • Phenylacetates
  • Ammonia
  • Benzoic Acid
  • phenylacetic acid