Macrophage colony-stimulating factor as a marker for malignant germ cell tumors of the ovary

Gynecol Oncol. 1998 Jan;68(1):35-7. doi: 10.1006/gyno.1997.4897.

Abstract

We assessed the usefulness of macrophage colony-stimulating factor (M-CSF) as a serum marker for malignant germ cell tumors of the ovary. Serum levels of M-CSF were measured in 49 patients with malignant germ cell tumors and in 64 patients with mature benign cystic teratoma by an enzyme-linked immunosorbent assay. CA125 was measured by radioimmunoassay. The serum level of M-CSF was above normal (>1056 U/ml) in 44 (90%) of 49 patients with malignant germ cell tumors; the CA125 level was above the cutoff value (35 U/ml) in 34 patients (69%) (P < 0.05). The serum level of M-CSF was elevated in 20 (87%) of 23 patients with stage I disease and in all 16 patients with dysgerminoma. Only 7 (11%) of 64 patients with mature benign cystic teratoma had elevated levels of M-CSF. These results suggest that M-CSF is highly sensitive and specific for malignant germ cell tumors of the ovary, especially for dysgerminoma.

MeSH terms

  • Biomarkers, Tumor / blood*
  • Dysgerminoma / blood
  • Dysgerminoma / diagnosis
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Germinoma / blood*
  • Germinoma / diagnosis
  • Humans
  • Macrophage Colony-Stimulating Factor / blood*
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / diagnosis
  • Radioimmunoassay
  • Sensitivity and Specificity
  • Teratoma / blood
  • Teratoma / diagnosis

Substances

  • Biomarkers, Tumor
  • Macrophage Colony-Stimulating Factor