Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice

Pharmacol Biochem Behav. 1976 Apr;4(4):381-4. doi: 10.1016/0091-3057(76)90051-4.


Male mice with high isolation-induced fighting tendencies were administered 200 mug 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice with less than 200 ng. NE/g persisted throughout a series of test fights, indicating no recovery in fighting behavior throughout the survival time.

MeSH terms

  • Aggression / drug effects*
  • Animals
  • Brain Chemistry / drug effects
  • Dopamine / analysis
  • Female
  • Humans
  • Hydroxydopamines / administration & dosage
  • Hydroxydopamines / pharmacology*
  • Injections, Intraventricular
  • Male
  • Mice
  • Norepinephrine / analysis
  • Social Isolation*


  • Hydroxydopamines
  • Dopamine
  • Norepinephrine