Early detection of cardiac damage with heart fatty acid-binding protein after cardiac operations

Ann Thorac Surg. 1998 Jan;65(1):54-8. doi: 10.1016/s0003-4975(97)01260-5.

Abstract

Background: It is still difficult to evaluate myocardial damage in the acute phase of reperfusion in cardiac operations. We investigated the clinical significance of human heart fatty acid-binding protein (HH-FABP) for detecting myocardial damage after cardiac operations earlier than creatine kinase MB isoform or troponin-T.

Methods: Blood samples from 20 patients who underwent coronary artery bypass grafting were collected serially after reperfusion to measure serum levels of creatine kinase-MB, troponin-T, and HH-FABP.

Results: Serum HH-FABP levels peaked earliest after reperfusion. In addition, the maximum serum HH-FABP level was predictable immediately after reperfusion. The maximum serum HH-FABP level correlated with the maximum serum creatine kinase-MB or troponin-T level, as well as with the aortic cross-clamp time or the maximum dose of catecholamines administered after reperfusion.

Conclusions: Measurements of HH-FABP allow for earlier evaluation of myocardial damage in the acute phase of reperfusion. Human heart fatty acid-binding protein may be a useful indicator of myocardial damage after cardiac operations.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood*
  • Carrier Proteins / blood*
  • Catecholamines / administration & dosage
  • Coronary Artery Bypass / adverse effects
  • Creatine Kinase / blood
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids / blood*
  • Female
  • Humans
  • Isoenzymes
  • Male
  • Middle Aged
  • Myelin P2 Protein / blood*
  • Myocardial Reperfusion Injury / diagnosis*
  • Neoplasm Proteins*
  • Troponin / blood
  • Tumor Suppressor Proteins*

Substances

  • Biomarkers
  • Carrier Proteins
  • Catecholamines
  • FABP7 protein, human
  • Fatty Acid-Binding Protein 7
  • Fatty Acid-Binding Proteins
  • Fatty Acids
  • Isoenzymes
  • Myelin P2 Protein
  • Neoplasm Proteins
  • Troponin
  • Tumor Suppressor Proteins
  • Creatine Kinase