The role of gender in heart transplantation

Ann Thorac Surg. 1998 Jan;65(1):88-94. doi: 10.1016/s0003-4975(97)01105-3.

Abstract

Background: The effect of donor and recipient gender on the outcome of heart transplantation (HT) remains uncertain.

Methods: One hundred seventy-four patients who underwent HT were divided into four groups according to donor and recipient gender. Group A consisted of 81 men who received male donor hearts, group B of 18 women who received female donor hearts, group C of 21 women who received male donor hearts, and group D of 54 men who received female donor hearts. All patients were treated by the same group of surgeons according to standard HT protocols. Comparisons were made between groups with regard to short- and long-term outcomes.

Results: Donor gender and recipient gender did not affect outcomes significantly. Overall, donor-recipient gender mismatching significantly increased the number of rejection episodes and reduced creatinine clearance, survival, and censored survival in the first year after HT (p < 0.05). More specifically, among female recipients, donor-recipient gender mismatching significantly increased the number of rejection episodes and decreased creatinine clearance in the first year after HT (p < 0.05); among male recipients, donor-recipient gender mismatching significantly reduced 1-year survival and censored survival to date after HT (p < 0.05).

Conclusions: Donor-recipient gender matching plays a significant role in determining HT outcomes.

MeSH terms

  • Adult
  • Creatinine / metabolism
  • Female
  • Graft Rejection
  • Heart Transplantation*
  • Hemodynamics
  • Humans
  • Male
  • Middle Aged
  • Sex Factors
  • Tissue Donors
  • Treatment Outcome

Substances

  • Creatinine