IgA class anti-beta2-glycoprotein I in patients with systemic lupus erythematosus

J Rheumatol. 1998 Jan;25(1):74-8.


Objective: To search for a possible relationship between the presence of IgA class anti-beta2-glycoprotein I antibody (abeta2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE).

Methods: Serum IgA abeta2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class abeta2-GPI were examined.

Results: Twenty-five percent of patients with SLE were positive for IgA abeta2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA abeta2-GPI, compared to those without. The presence of IgA abeta2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA abeta2-GPI significantly correlated with values of IgG abeta2-GPI, IgM abeta2-GPI, and anti-DNA antibodies.

Conclusion: The presence of IgA abeta2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA abeta2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Anticardiolipin / blood
  • Biomarkers / blood
  • Glycoproteins / immunology*
  • Glycoproteins / metabolism
  • Humans
  • Immunoglobulin A / blood*
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / immunology*
  • Reference Values
  • beta 2-Glycoprotein I


  • Antibodies, Anticardiolipin
  • Biomarkers
  • Glycoproteins
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • beta 2-Glycoprotein I