Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death

M Takahashi; Y Yamamoto; S Hatori; M Shiozawa; M Suzuki; Y Rino; T Amano; T Imada

Enhancement of CDDP cytotoxicity by caffeine is characterized by apoptotic cell death

Oncol Rep. 1998 Jan-Feb;5(1):53-6.

Authors

M Takahashi¹, Y Yamamoto, S Hatori, M Shiozawa, M Suzuki, Y Rino, T Amano, T Imada

Affiliation

¹ First Department of Surgery, Yokohama City University, School of Medicine, Japan.

PMID: 9458292

Abstract

Through the use of STKM-1 human stomach cancer cells, we investigated the enhancement of the anti-tumor effect and the apoptosis induction of the CDDP and caffeine combination. Even when the concentration of CDDP was low, CDDP significantly decreased the proliferation of STKM-1 human stomach cancer cells, thus confirming the synergistic effect of the CDDP and caffeine group. The apoptotic labeling index of the CDDP plus caffeine combination was significantly higher than that of the CDDP group. In conclusion, caffeine enhanced the effect of CDDP by not only inhibiting DNA repairs but also inducing apoptosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis* / drug effects
Caffeine / toxicity*
Cell Division / drug effects
Cisplatin / toxicity*
Drug Synergism
Humans
Mitotic Index / drug effects
Stomach Neoplasms / pathology*
Tumor Cells, Cultured

Substances

Caffeine
Cisplatin