Second primary extracolonic cancers in Japanese hereditary nonpolyposis colorectal cancer

Oncol Rep. Jan-Feb 1998;5(1):143-5.

Abstract

We examined the occurrence of second primary extracolonic cancers in 1,170 patients with nonpolyposis colorectal cancer who underwent a resection between 1972 and 1994. Such cancers occurred more often in cases with hereditary nonpolyposis colorectal cancer (HNPCC) than in those without (11.1% vs. 3.6%, P=0.0286). Five HNPCC cases developed 6 cancers in the stomach, endometrium, ovary, and ureter. The mean interval between the first and second operation was 66 months (range: 18-153). These findings thus indicate the importance of targetted surveillance for any second primary cancers in the upper gastrointestinal, female genital, or upper urologic tract, especially in HNPCC patients.

MeSH terms

  • Adult
  • Aged
  • Colonic Neoplasms / pathology*
  • Colonic Neoplasms / surgery
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / pathology*
  • Colorectal Neoplasms, Hereditary Nonpolyposis / surgery
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / surgery
  • Female
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Neoplasms, Second Primary / pathology*
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Rectal Neoplasms / pathology*
  • Rectal Neoplasms / surgery
  • Reoperation
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery
  • Ureteral Neoplasms / pathology*
  • Ureteral Neoplasms / surgery