Abstract
An immunohistochemical evaluation of Le(a)-Le(x) expression by adenocarcinomas of the biliary tree, pancreas, colon and stomach was undertaken as examples of epithelial tumors derived from embryonic endoderm. This complements previous studies showing that Lea-Lex was present on the cell surface of non-small cell lung carcinomas, some non-lung carcinomas, and is a prognostic marker for squamous cell lung carcinomas. All of the tumor specimen evaluated were positive and no expression of Le(a)-Le(x) was detected in derivatives of neural, connective or muscle tissues. These findings indicate that it could be informative to examine the biological significance of Le(a)-Le(x) not only in carcinogenesis but during embryogenesis, as well.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenocarcinoma / pathology*
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Adenocarcinoma / surgery
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Biomarkers, Tumor / analysis*
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Carcinoma, Non-Small-Cell Lung / pathology
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Colonic Neoplasms / pathology
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Embryo, Mammalian
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Endoderm
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Gallbladder Neoplasms / pathology
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Gastric Mucosa / pathology
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Humans
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Immunohistochemistry / methods
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Intestinal Mucosa / pathology
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Lewis Blood Group Antigens
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Lewis X Antigen
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Lung Neoplasms / pathology
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Metaplasia
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Neoplasms, Squamous Cell / pathology
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Oligosaccharides / analysis*
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Pancreatic Neoplasms / pathology
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Prognosis
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Stomach Neoplasms / pathology
Substances
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Biomarkers, Tumor
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Lewis Blood Group Antigens
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Lewis X Antigen
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Oligosaccharides
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lewis(a)-lewis(x)