Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues

Int J Oncol. 1998 Feb;12(2):309-13. doi: 10.3892/ijo.12.2.309.


We investigated the mRNA expression of the human endogenous retrovirus ERV3 (HERV-R) in several normal and corresponding tumor tissues. The env gene of ERV3 is expressed as mRNA in several tissues. Comparison of ERV3 mRNA expression by Northern analyses, revealed a non-systematic variation. Expression was shown to be particularly high in the adrenal gland and some cases of lung cancer. This tissue-tropism should be seen in relation to the high expression previously found in syncytiotrophoblasts in placenta and sebaceous glands of the skin, suggesting profound influences by steroid hormonal regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Northern
  • Endogenous Retroviruses / genetics*
  • Endogenous Retroviruses / metabolism
  • Gene Expression
  • Genes, Viral
  • Humans
  • In Situ Hybridization
  • Neoplasms / genetics
  • Neoplasms / virology*
  • Nucleic Acid Hybridization
  • Polymorphism, Genetic
  • RNA, Messenger / biosynthesis*
  • RNA, Viral / biosynthesis*
  • Tissue Distribution
  • Trophoblasts


  • RNA, Messenger
  • RNA, Viral