Genetic Alterations in the Development of Mammary and Prostate Cancer in the C3(1)/Tag Transgenic Mouse Model

Int J Oncol. 1998 Feb;12(2):449-53.

Abstract

We have generated a transgenic mouse model in which female mice develop ductal mammary adenocarcinomas and male mice develop prostatic adenocarcinomas by using a transgene containing the hormone-responsive rat prostatic steroid binding protein 5' flanking region C3(1) fused to the simian virus 40 (SV40) large T antigen. We have identified some genetic alterations during mammary and prostate tumor progression: (i) p53 is functionally inactivated during mammary cancer development without p53 mutations; (ii) Alterations in apoptosis during mammary tumor progression are p53 and bcl-2 independent; (iii) Ha-ras mutations occur early in the development of prostate cancer. This unique animal model offers the opportunity to study multistep tumorigenesis in these organs.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / genetics*
  • Animals
  • Apoptosis / genetics
  • Breast Neoplasms / genetics*
  • Disease Models, Animal
  • Female
  • Genes, bcl-2 / genetics
  • Genes, p53 / genetics
  • Genes, ras / genetics
  • Male
  • Mammary Neoplasms, Animal / genetics*
  • Mice
  • Mice, Transgenic
  • Mutation
  • Phenotype
  • Prostatic Neoplasms / genetics*
  • Rats