Current concepts in mucosal immunity. I. Antigen presentation in the intestine: new rules and regulations

Am J Physiol. 1998 Jan;274(1):G7-9. doi: 10.1152/ajpgi.1998.274.1.G7.


The recognition that immune responses in the intestine differ from those seen systemically has led to a search for novel pathways involved in mucosal immunoregulation. One cell type that has surfaced as a prime candidate for such a regulatory role is the intestinal epithelial cell. A number of laboratories have documented that intestinal epithelial cells sample luminal antigens and process and present these to primed T cells. However, several unique features have emerged, making their potential role as antigen-presenting cells a critical part of mucosal homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Homeostasis / immunology
  • Humans
  • Immunity, Mucosal / physiology*
  • Intestinal Mucosa / immunology*
  • Models, Immunological
  • T-Lymphocytes / immunology