Apamin, a blocker of the calcium-activated potassium channel, induces neurodegeneration of Purkinje cells exclusively

Brain Res. 1997 Dec 19;778(2):405-8. doi: 10.1016/s0006-8993(97)01165-7.


Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. These data demonstrate that the inactivation of small conductance Ca2+-activated K+ channels by apamin induces a non-limbic neurodegeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apamin / pharmacology*
  • Calcium / physiology
  • Epilepsy / pathology
  • Injections, Intraventricular
  • Male
  • Nerve Degeneration / chemically induced*
  • Potassium Channel Blockers*
  • Purkinje Cells / drug effects*
  • Purkinje Cells / pathology
  • Rats
  • Rats, Sprague-Dawley


  • Potassium Channel Blockers
  • Apamin
  • Calcium