Cervical amyloidoma of C2. Case report and review of the literature

Spine (Phila Pa 1976). 1998 Jan 1;23(1):133-8. doi: 10.1097/00007632-199801010-00027.


Study design: Second published report of a patient with amyloidoma of the upper cervical spine.

Objectives: To describe a patient with rare radiculopathy to alert other physicians to consider amyloid tumor as a differential diagnosis of locally destructive spine lesions.

Summary of background data: Localized amyloid tumor of the bone is a rare disease. Only seven cases of spine involvement have been reported. Appropriate tissue sampling is required to establish the diagnosis. Histopathologic examination shows pathognomonic apple-green birefringence under polarized light. When bone is involved with amyloid, it is most commonly associated with multiple myeloma or other plasma cell-dyscrasias.

Method: This case was described, and pertinent literature was reviewed.

Results: The patient showed persistent neurologic improvement after transoral complete tumor removal, followed by a secondary posterior stabilization procedure using transarticular C1-C2 screws.

Conclusions: Amyloidomas are benign lesions with no associated documented risk for the development of plasmocytoma-related diseases. The clinical and radiographic manifestations of this lesion are nonspecific. A cure is possible with complete resection of the tumor and no adjuvant management procedures.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Amyloidosis / diagnostic imaging*
  • Amyloidosis / pathology
  • Amyloidosis / surgery*
  • Bone Screws
  • Cervical Vertebrae / diagnostic imaging*
  • Humans
  • Male
  • Spinal Cord Neoplasms / diagnostic imaging*
  • Spinal Cord Neoplasms / surgery*
  • Spinal Fusion
  • Tomography, X-Ray Computed