Paint-remover hazard

JAMA. 1976 Jan 26;235(4):398-401.


The in-home use of paint removers containing methylene chloride results in the absorption of this solvent, which is metabolized to carbon monoxide. Exposure for two to three hours can result in the elevation of carboxyhemoglobin (COHb) to levels that stress the cardiovascular system. The metabolic formation of COHb continues following the paint-remover exposure, doubling the duration of the cardiovascular stress produced by a comparable COHb level after exposure to CO. Patients with diseased cardiovascular systems may not be able to tolerate this unexpected stress.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Carbon Monoxide / metabolism
  • Carbon Monoxide / toxicity*
  • Carboxyhemoglobin / analysis
  • Cardiovascular System / drug effects
  • Environmental Exposure
  • Humans
  • Hydrocarbons, Chlorinated / metabolism*
  • Male
  • Methylene Chloride / metabolism*
  • Middle Aged
  • Myocardial Infarction / etiology
  • Occupational Medicine
  • Paint*
  • Solvents / metabolism*
  • Ventilation


  • Hydrocarbons, Chlorinated
  • Solvents
  • Methylene Chloride
  • Carbon Monoxide
  • Carboxyhemoglobin