A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13

Kidney Int. 1998 Feb;53(2):282-6. doi: 10.1046/j.1523-1755.1998.00828.x.

Abstract

We performed a genome-wide linkage analysis search for a genetic locus responsible for kidney dysfunction in a large family. This inherited condition, characterized by proteinuria, progressive renal insufficiency, and focal segmental glomerulosclerosis, follows autosomal dominant inheritance. We show with a high degree of certainty (maximum 2-point lod score 12.28) that the gene responsible for this condition is located on chromosome 19q13.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping*
  • Chromosomes, Human, Pair 19*
  • Family Health
  • Female
  • Glomerulosclerosis, Focal Segmental / genetics*
  • Glomerulosclerosis, Focal Segmental / pathology
  • Haplotypes
  • Humans
  • Male
  • Pedigree