Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury

J Biol Chem. 1998 Feb 13;273(7):4135-42. doi: 10.1074/jbc.273.7.4135.


We report the identification of rat and human cDNAs for a type 1 membrane protein that contains a novel six-cysteine immunoglobulin-like domain and a mucin domain; it is named kidney injury molecule-1 (KIM-1). Structurally, KIM-1 is a member of the immunoglobulin gene superfamily most reminiscent of mucosal addressin cell adhesion molecule 1 (MAdCAM-1). Human KIM-1 exhibits homology to a monkey gene, hepatitis A virus cell receptor 1 (HAVcr-1), which was identified recently as a receptor for the hepatitis A virus. KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. In situ hybridization and immunohistochemistry revealed that KIM-1 is expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules. Structure and expression data suggest that KIM-1 is an epithelial cell adhesion molecule up-regulated in the cells, which are dedifferentiated and undergoing replication. KIM-1 may play an important role in the restoration of the morphological integrity and function to postischemic kidney.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Adhesion Molecules / chemistry*
  • Cloning, Molecular
  • Gene Expression Regulation / genetics
  • Immunoglobulins / chemistry*
  • Immunohistochemistry
  • In Situ Hybridization
  • Ischemia / metabolism
  • Kidney / chemistry
  • Kidney / injuries*
  • Male
  • Membrane Proteins*
  • Molecular Sequence Data
  • RNA, Messenger / analysis
  • Rats
  • Rats, Sprague-Dawley
  • Recombinant Proteins / genetics
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Up-Regulation / physiology


  • Cell Adhesion Molecules
  • Havcr1protein, rat
  • Immunoglobulins
  • Membrane Proteins
  • RNA, Messenger
  • Recombinant Proteins

Associated data

  • GENBANK/AF035963