Antibacterial constituents of the Nepalese medicinal herb, Centipeda minima

Phytochemistry. 1998 Feb;47(4):631-4. doi: 10.1016/s0031-9422(97)00534-7.

Abstract

Centipeda minima, a herb used medicinally to treat sinus infections in Nepal, was found to contain three antibacterial sesquiterpene lactones, identified as 6-O-methylacrylylplenolin, 6-O-isobutyroylplenolin, and 6-O-angeloylplenolin. 6-O-Methylacrylylplenolin had not been previously isolated from C. minima. All three had activity against Bacillus subtilis and Staphylococcus aureus, with 6-O-isobutyroylplenolin being the most active.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Methicillin Resistance
  • Microbial Sensitivity Tests
  • Nepal
  • Phytotherapy
  • Plants, Medicinal*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Lactones
  • Sesquiterpenes