Comparison of dose doubling with probenecid for sustaining serum cefuroxime levels

J Antimicrob Chemother. 1997 Dec;40(6):903-6. doi: 10.1093/jac/40.6.903.

Abstract

Serum cefuroxime concentrations were measured over a 12 h period in ten healthy adults following three iv dosing regimens: 750 mg cefuroxime, 1.5 g cefuroxime, and 750 mg cefuroxime with 1 g of probenecid given orally 3 h before the cefuroxime infusion. Probenecid prolonged the serum cefuroxime half-life by 63% (P < 0.05) with a significant increase in the mean time for which serum cefuroxime concentrations exceeded the MIC90 for common respiratory pathogens (2 mg/L) compared with either 750 mg cefuroxime (2.2 h, P < 0.05) or 1.5 g of cefuroxime (0.9 h, P < 0.05) without probenecid. The cost of the 750 mg cefuroxime dose plus probenecid is approximately half that of a 1.5 g cefuroxime dose.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Area Under Curve
  • Biological Availability
  • Cefuroxime / pharmacokinetics*
  • Cephalosporins / pharmacokinetics*
  • Drug Interactions
  • Female
  • Half-Life
  • Humans
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Probenecid / administration & dosage
  • Probenecid / pharmacology*
  • Renal Agents / pharmacology*

Substances

  • Cephalosporins
  • Renal Agents
  • Cefuroxime
  • Probenecid