Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 8 (3), 207-19

The Immunobiology of Interferon-Gamma Inducible Protein 10 kD (IP-10): A Novel, Pleiotropic Member of the C-X-C Chemokine Superfamily

Affiliations
Review

The Immunobiology of Interferon-Gamma Inducible Protein 10 kD (IP-10): A Novel, Pleiotropic Member of the C-X-C Chemokine Superfamily

L F Neville et al. Cytokine Growth Factor Rev.

Abstract

Interferon-gamma inducible protein 10 kD (IP-10) is a highly inducible, primary response gene that belongs to the C-X-C chemokine superfamily. Despite the original cloning of IP-10 in 1985, its biological functions are still unclear although accumulating reports indicate that it is a pleiotropic molecule capable of eliciting potent biological effects, including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. More interest is now likely to be focused on IP-10 due to the recent cloning of an IP-10 receptor. This paper aims to highlight our current knowledge of IP-10 and its homologues as well as defining its likely involvement in regulating fibroproliferation following inflammatory lung injury.

Similar articles

See all similar articles

Cited by 103 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback