The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily

Cytokine Growth Factor Rev. 1997 Sep;8(3):207-19. doi: 10.1016/s1359-6101(97)00015-4.


Interferon-gamma inducible protein 10 kD (IP-10) is a highly inducible, primary response gene that belongs to the C-X-C chemokine superfamily. Despite the original cloning of IP-10 in 1985, its biological functions are still unclear although accumulating reports indicate that it is a pleiotropic molecule capable of eliciting potent biological effects, including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. More interest is now likely to be focused on IP-10 due to the recent cloning of an IP-10 receptor. This paper aims to highlight our current knowledge of IP-10 and its homologues as well as defining its likely involvement in regulating fibroproliferation following inflammatory lung injury.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemokine CXCL10
  • Chemokines / genetics*
  • Chemokines / immunology*
  • Chemokines, CXC*
  • Humans
  • Interferon-gamma / pharmacology*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • Chemokine CXCL10
  • Chemokines
  • Chemokines, CXC
  • Interferon-gamma