Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population

Am J Cardiol. 1998 Jan 1;81(1):83-6. doi: 10.1016/s0002-9149(97)10806-2.

Abstract

We investigated the association between variations in the endothelial constitutive nitric oxide synthase (ecNOS) gene and the presence of myocardial infarction. The results indicate that the mutant allele (ecNOS'4a) is an independent risk factor for myocardial infarction in the Japanese population, especially in those lacking other conventional risk factors.

MeSH terms

  • Aged
  • Asian Continental Ancestry Group / genetics*
  • Base Sequence
  • Case-Control Studies
  • DNA / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Myocardial Infarction / enzymology*
  • Myocardial Infarction / genetics*
  • Nitric Oxide Synthase / genetics*
  • Nitric Oxide Synthase Type III
  • Polymorphism, Genetic / genetics*
  • Repetitive Sequences, Nucleic Acid / genetics*
  • Risk Factors

Substances

  • DNA
  • NOS3 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type III