Release of protein and cations from the lens in the presence of different antigen-antibody interactions

Mod Probl Ophthalmol. 1976;16:80-94.

Abstract

Rabbit lenses exposed to unrelated Ag/Ab interactions and to heterologous anti-lens and anti-uveo-retinal antibodies show alterations of their permeability with loss of Rb+ followed by efflux of macromolecular intracellular constituents; these phenomena take place also without complement when the ratio of the unrelated Ag/ab is in Ag excess, while complement is strictly required for the action of anti-tissue antibodies. The possible role of these findings as regards the pathogenesis of complicated cataracts in uveitis and the self-maintenance of recurrent uveitis is briefly discussed.

MeSH terms

  • Animals
  • Antibodies
  • Antibodies, Heterophile
  • Antigen-Antibody Reactions*
  • Cations, Divalent
  • Cattle
  • Crystallins / immunology
  • Crystallins / metabolism*
  • Guinea Pigs
  • Permeability
  • Rabbits
  • Retina / immunology
  • Uvea / immunology
  • Uveitis / immunology

Substances

  • Antibodies
  • Antibodies, Heterophile
  • Cations, Divalent
  • Crystallins