Congenital graves disease. Four familial cases with long-term follow-up and perspective

Am J Dis Child. 1976 Feb;130(2):148-55. doi: 10.1001/archpedi.1976.02120030038008.


Congenital Graves disease has been described as a transient disorder in which the mother has or has had hyperthyroidism. Experience with four affected children to ages 5 to 9 years and a review of published cases led us to conclude that long-acting thyroid stimulator (half-life, six days) is not the cause of the disease. This disease occurs in infants from families with a high incidence of Graves disease, and, in many, hyperthyroidism persists for months or years. The pathogenesis of Graves disease is unknown, and the simplistic maternal-to-fetal humoral theory is not a suitable explanation for congenital Graves disease. If Graves disease is considered in the larger perspective than the maternal-fetal unit, a pattern of inheritance is apparent, ie, an autosomal-dominant trait with a predilection for the female individual.

MeSH terms

  • Child
  • Child, Preschool
  • Diseases in Twins
  • Female
  • Follow-Up Studies
  • Graves Disease / blood
  • Graves Disease / congenital*
  • Graves Disease / genetics
  • Humans
  • Hyperthyroidism / complications
  • Infant, Newborn
  • Long-Acting Thyroid Stimulator / blood
  • Male
  • Pedigree


  • Long-Acting Thyroid Stimulator