The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents

Arch Toxicol. 1976 Jan 30;35(1):15-24. doi: 10.1007/BF00333982.

Abstract

Among 15 chelating agents tested, sodium-2,3-dimercaptopropane 1 sulfonate (DMPS), 2,3-dimercaptopropanol (BAL), sodium-mercaptoethyliminodiacetate (MEIDA), and D-penicillamine (PA) exerted an influence on the excretion of Hg and its distribution in the organs. The excretion pattern however, is different for these compounds, and, from the practical point of view, a favourable effect is exhibited only by DMPS which enhances the urinary excretion rate and lowers the Hg-concentration in all organs.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Chelating Agents / therapeutic use*
  • Dimercaprol / therapeutic use
  • Disease Models, Animal
  • Feces / analysis
  • Kidney / metabolism
  • Ligands / therapeutic use
  • Male
  • Mercury / metabolism
  • Mercury / urine
  • Mercury Poisoning / drug therapy*
  • Penicillamine / therapeutic use
  • Rats
  • Sulfhydryl Compounds / therapeutic use

Substances

  • Chelating Agents
  • Ligands
  • Sulfhydryl Compounds
  • Dimercaprol
  • Mercury
  • Penicillamine