Polyamine Profiles in the Urine of Patients With Leukemia

Cancer Lett. 1998 Jan 9;122(1-2):1-8. doi: 10.1016/s0304-3835(97)00399-6.

Abstract

Eleven urinary polyamine levels were determined in controls (32 cases) and 43 patients with varying stages of leukemia including initial, relapse and complete remission, using gas chromatography nitrogen-phosphorus detection. Also, to indirectly evaluate the possible involvement of enzymes, precursor to product concentration ratios were compared between controls and patients with each stage of leukemia. As a result, it is confirmed that the ratio of N1-acSpd/N8-acSpd could be used as a diagnostic marker and the level of N1,N12-diacetylspermine could be used for determining disease stage and as a malignancy marker for leukemia. An altered metabolic pathway related to leukemia is also proposed in which N1,N12-diacetylspermine can be produced directly from spermine and N1,N12-diacetylspermine is a major source of N1-acetylspermidine.

MeSH terms

  • Adolescent
  • Adult
  • Biogenic Polyamines / urine*
  • Biomarkers, Tumor / urine
  • Female
  • Humans
  • Leukemia / urine*
  • Male
  • Middle Aged

Substances

  • Biogenic Polyamines
  • Biomarkers, Tumor