Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

Cancer Lett. 1998 Jan 9;122(1-2):165-75. doi: 10.1016/s0304-3835(97)00387-x.


A single dose of 75 mg/kg 7,12 dimethylbenz[a]anthracene was administered to 50-day-old virgin female Sprague-Dawley rats and 100 days later, animals were randomized and provided with Teklad rodent chow mixed with a dose of 25 mg/rat/day ibuprofen for 35 days. Ibuprofen treatment reduced tumor volume (P < 0.05) and significantly inhibited gene expression of both cyclooxygenase- and cyclooxygenase-2 (P < 0.02). These results indicate that ibuprofen induced significant regression of established mammary carcinomas which was associated with inhibition of expression of isoforms of the gene responsible for prostaglandin production.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Female
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Ibuprofen / pharmacology*
  • Mammary Neoplasms, Experimental / chemically induced
  • Mammary Neoplasms, Experimental / enzymology*
  • Prostaglandin-Endoperoxide Synthases / genetics*
  • Rats
  • Rats, Sprague-Dawley


  • Anti-Inflammatory Agents, Non-Steroidal
  • 9,10-Dimethyl-1,2-benzanthracene
  • Prostaglandin-Endoperoxide Synthases
  • Ibuprofen