Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody-drug conjugate

Cancer Lett. 1998 Jan 9;122(1-2):231-6. doi: 10.1016/s0304-3835(97)00401-1.

Abstract

The murine monoclonal antibody A7 (MAb A7) is reactive against most human gastric cancer cell lines. Using a nude mouse peritoneal dissemination model of human gastric cancer, we investigated targeted chemotherapy using a conjugate of neocarzinostatin (NCS) with MAb A7 (A7-NCS). After demonstrating cytotoxicity of the complex against the human gastric cancer cell line MKN45 in vitro, we intraperitoneally injected A7-NCS, NCS or saline into nude mice bearing peritoneally disseminated human gastric cancer. A7-NCS inhibited peritoneal dissemination significantly more effectively than NCS. MAb A7 may prove to be an effective carrier for antineoplastic drugs in patients with peritoneal dissemination of gastric cancer.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use
  • Humans
  • Immunotoxins / therapeutic use*
  • Male
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Peritoneal Neoplasms / drug therapy*
  • Stomach Neoplasms / drug therapy*
  • Tumor Cells, Cultured
  • Zinostatin / therapeutic use*

Substances

  • Antibiotics, Antineoplastic
  • Antibodies, Monoclonal
  • Immunotoxins
  • Zinostatin