Reduction of amphotericin B nephrotoxicity with mannitol

JAMA. 1976 May 3;235(18):1995-6.

Abstract

Amphotericin B in combination with mannitol was given to a patient who had mucocutaneous candidiasis and moderate renal insufficiency. Previously, amphotericin B alone had induced an abrupt increase in serum creatinine and urea nitrogen, but when mannitol was given concurrently there was no worsening of renal function. Thus, amphotericin B with mannitol appears to offer a less nephrotoxic but equally candicidal therapeutic regimen in the renal compromised patient requiring parenteral candicidal therapy.

MeSH terms

  • Adolescent
  • Adult
  • Amphotericin B / adverse effects*
  • Amphotericin B / antagonists & inhibitors
  • Amphotericin B / therapeutic use
  • Candidiasis / complications
  • Candidiasis / drug therapy
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney / drug effects*
  • Mannitol / pharmacology*
  • Mannitol / therapeutic use
  • Nephritis, Interstitial / complications
  • Nephrocalcinosis / complications
  • Skin Diseases, Infectious / drug therapy
  • Transfer Factor / administration & dosage

Substances

  • Transfer Factor
  • Mannitol
  • Amphotericin B