Phosphatases and tumorigenesis

Curr Opin Oncol. 1998 Jan;10(1):88-91. doi: 10.1097/00001622-199801000-00014.

Abstract

Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the etiology of tumors: protein phosphatase 2A, CDC25A/B, and PTEN (or MMAC1). Protein phosphatase 2A and PTEN behave as tumor suppressors, whereas CDC25A and -B act as oncogenes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Female
  • GTP-Binding Proteins / genetics*
  • GTP-Binding Proteins / metabolism
  • Gene Expression Regulation, Enzymologic
  • Genes, Tumor Suppressor / genetics
  • Humans
  • Male
  • Neoplasms / enzymology*
  • Neoplasms / etiology
  • Oncogenes / genetics
  • PTEN Phosphohydrolase
  • Phosphoprotein Phosphatases / genetics*
  • Phosphoprotein Phosphatases / metabolism
  • Phosphoric Monoester Hydrolases*
  • Protein Phosphatase 2
  • Protein Tyrosine Phosphatases / genetics*
  • Protein Tyrosine Phosphatases / metabolism
  • Tumor Suppressor Proteins*
  • cdc25 Phosphatases

Substances

  • Cell Cycle Proteins
  • Tumor Suppressor Proteins
  • Phosphoprotein Phosphatases
  • Protein Phosphatase 2
  • Phosphoric Monoester Hydrolases
  • Protein Tyrosine Phosphatases
  • cdc25 Phosphatases
  • PTEN Phosphohydrolase
  • PTEN protein, human
  • GTP-Binding Proteins