Mice lacking the murine interleukin-8 receptor homologue demonstrate paradoxical responses to acute and chronic experimental infection with Listeria monocytogenes

Microb Pathog. 1998 Jan;24(1):17-23. doi: 10.1006/mpat.1997.0169.

Abstract

In this study we demonstrate that mice which lack the murine interleukin-8 receptor homologue exhibit enhanced resistance during the early stage of infection (1-4 days after i.v. challenge with Listeria monocytogenes). This result is surprising in that interleukin-8 and other CXC chemokines are key players in the accumulation of inflammatory neutrophils, which is thought to be critical for resistance to listeriosis. Paradoxically, some of the interleukin-8 receptor knockout mice that survived acute infection with L. monocytogenes demonstrated evidence of chronic infection with L. monocytogenes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acute Disease
  • Animals
  • Antigens, CD / genetics
  • Antigens, CD / physiology*
  • Chronic Disease
  • Interleukin-8 / physiology*
  • Listeria monocytogenes / immunology
  • Listeria monocytogenes / pathogenicity*
  • Listeriosis / immunology*
  • Listeriosis / microbiology
  • Listeriosis / pathology
  • Liver / microbiology
  • Liver / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin / physiology*
  • Receptors, Interleukin-8A
  • Spleen / microbiology
  • Spleen / pathology

Substances

  • Antigens, CD
  • Interleukin-8
  • Receptors, Interleukin
  • Receptors, Interleukin-8A