Bilateral zonular cataract associated with the mitochondrial cytopathy of Pearson syndrome

Am J Ophthalmol. 1998 Feb;125(2):260-1. doi: 10.1016/s0002-9394(99)80105-6.


Purpose: To report a child with the mitochondrial cytopathy of Pearson syndrome and zonular cataract.

Method: Case report. We describe a 6-year-old boy with Pearson syndrome.

Results: At age 3 years, the boy developed secondary strabismus caused by bilateral zonular cataract. Subsequently, he underwent successful bilateral cataract extraction with intraocular lens implantation. Postoperative visual acuity with best correction was RE, 20/25 and LE, 20/40.

Conclusions: Children with Pearson syndrome should be examined ophthalmologically to rule out zonular cataract and possible amblyopia. Mitochondrial cytopathies such as Pearson syndrome should be included in the differential diagnosis of congenital and early juvenile cataract.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Sideroblastic / complications*
  • Anemia, Sideroblastic / pathology
  • Bone Marrow Diseases / complications*
  • Bone Marrow Diseases / pathology
  • Cataract / etiology*
  • Cataract Extraction
  • Child
  • DNA, Mitochondrial / genetics
  • Gene Deletion
  • Growth Disorders / complications*
  • Growth Disorders / pathology
  • Humans
  • Lens Implantation, Intraocular
  • Male
  • Mitochondria / pathology*
  • Syndrome


  • DNA, Mitochondrial