Sulphatoxymelatonin excretion in older people: relationship to plasma melatonin and renal function

J Pineal Res. 1998 Jan;24(1):58-61. doi: 10.1111/j.1600-079x.1998.tb00366.x.


In order to validate measurement of urinary sulphatoxymelatonin as an accurate method of estimating plasma melatonin secretion in older people, we compared 24 h plasma melatonin secretion and sulphatoxymelatonin excretion with renal function in 20 subjects 62-89 years of age. There was a good correlation between plasma and urinary sulphatoxymelatonin over the same 24 h period (R2 = 0.797) and no relationship between creatinine clearance and sulphatoxymelatonin excretion (R2 = 0.075). The results suggest that sulphatoxymelatonin excretion estimation is a good surrogate measurement of plasma melatonin secretion in older people, at least across the range of creatinine clearance for the subjects in the study, 0.41-1.81 ml/sec.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Creatinine / urine
  • Female
  • Humans
  • Kidney / physiology*
  • Male
  • Melatonin / analogs & derivatives*
  • Melatonin / blood*
  • Melatonin / urine
  • Middle Aged
  • Pineal Gland / metabolism


  • 6-sulfatoxymelatonin
  • Creatinine
  • Melatonin