Angiogenesis in esophageal squamous cell carcinoma

Oncol Rep. 1998 Mar-Apr;5(2):401-4. doi: 10.3892/or.5.2.401.


We retrospectively analyzed the prognostic significance of angiogenesis and the relationships between tumor angiogenesis and clinopathological variables in a series of 127 patients with primary esophageal squamous cell carcinoma which were curatively resected. Vessels were stained with anti-factor VIII polyclonal antibody and areas with the highest number of microvessels were counted in a x400 field. Microvessel counts were significantly correlated with pN category, pM category, venous invasion and recurrence (p=0.002, p=0.040, p=0.016 and p=0.0013, respectively). The proportion of patients with recurrence increased in proportion to the number of microvessels. multivariate analysis using Cox's proportional hazard modelling showed angiogenesis assessed by microvessel count affected the poorer prognosis of patients with esophageal squamous cell carcinoma (hazard ratio, 1.03; 95%CI, 1.00-1.07), although it was not a significant independent prognostic factor (P=0.088). This study suggest that angiogenesis assessed by microvessel count is a marker for relapse and prognosis in patients with esophageal squamous cell carcinoma.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / blood supply*
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology
  • Esophageal Neoplasms / blood supply*
  • Esophageal Neoplasms / metabolism
  • Esophageal Neoplasms / pathology
  • Factor VIII / metabolism
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / pathology*
  • Prognosis
  • Proportional Hazards Models
  • Retrospective Studies
  • Survival Analysis


  • Factor VIII