Up-regulation of beta-actin, cyclophilin and GAPDH in N1S1 rat hepatoma

Oncol Rep. Mar-Apr 1998;5(2):469-71. doi: 10.3892/or.5.2.469.


Beta-actin, cyclophilin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are all constantly expressed proteins that regulate cellular structures and endogenous cytoarchitectural functions. In this study, we used an in vivo N1S1 rat hepatoma model to examine changes in the expression levels of these housekeeping genes in normal and tumor liver samples. The beta-actin, cyclophilin and GAPDH genes were all up-regulated in tumor groups as compared to the controls. Our results suggest that up-regulation of beta-actin, cyclophilin and GAPDH genes may be essential for oncogenesis in hepatoma.

MeSH terms

  • Actins / genetics
  • Actins / metabolism*
  • Animals
  • Blotting, Northern
  • Gene Expression Regulation / genetics*
  • Glyceraldehyde-3-Phosphate Dehydrogenases / genetics
  • Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism*
  • Liver Neoplasms, Experimental / genetics
  • Liver Neoplasms, Experimental / metabolism*
  • Male
  • Neoplasm Transplantation
  • Peptidylprolyl Isomerase / genetics
  • Peptidylprolyl Isomerase / metabolism*
  • RNA, Neoplasm / isolation & purification
  • RNA, Neoplasm / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Up-Regulation*


  • Actins
  • RNA, Neoplasm
  • Glyceraldehyde-3-Phosphate Dehydrogenases
  • Peptidylprolyl Isomerase