Viral vectors for gene therapy

Trends Biotechnol. 1998 Jan;16(1):35-40. doi: 10.1016/S0167-7799(97)01137-2.


Gene therapy is now being applied to the treatment of wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses, herpes-simplex viruses and adeno-associated viruses. These viral vectors have a number of specific advantages and disadvantages that make them suited to particular gene-therapeutic applications. This review will summarize the current status of the development of viral vectors for gene therapy.

Publication types

  • Review

MeSH terms

  • Adenoviridae / genetics
  • Dependovirus / genetics
  • Genetic Therapy*
  • Genetic Vectors*
  • Humans
  • Retroviridae / genetics
  • Simplexvirus / genetics
  • Viruses / genetics*