Gammadelta T cells in host defense and epithelial cell biology

Clin Immunol Immunopathol. 1998 Feb;86(2):121-33. doi: 10.1006/clin.1997.4468.


Recent studies have demonstrated increased numbers of gammadelta T cells in a variety of human infectious as well as noninfectious diseases. In some cases gammadelta T cells could be shown to destroy infected or transformed cells. Advances in the identification of ligands recognized by gammadelta T cells and the development of animal model systems to study these cells in vivo should overcome some of the major obstacles currently preventing a better understanding of gammadelta T cell function in immune responses. As we gain this knowledge it may become possible to design therapeutic strategies exploiting unique properties of gammadelta T cells to promote more effective immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Epithelium / immunology
  • Humans
  • Immunity*
  • Infections / immunology*
  • Models, Immunological
  • Receptors, Antigen, T-Cell, gamma-delta / immunology*
  • T-Lymphocytes / immunology*


  • Receptors, Antigen, T-Cell, gamma-delta